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Showing posts from January, 2013

Is BlueBrain worth the Billion Dollars? Ask the Zebrafish

Remember the Zebrafish ? That likeable little thing is termed the 'workhorse' model organism in developmental biology (and nobody has a problem with this metaphor). Be it as it is - Zebrafish are the pet model organism for brain studies for essentially two reasons: they are easy to breed - and the larvae are transparent, allowing for easy access to neuronal imaging. Recently Florian Engert and coworkers put paralysed zebrafish larvae in an experimental setup that is highly reminiscent of The Matrix, letting the fishlet experience a virtual world of environment-simulations and study the reactions to the stimuli by optically monitoring brain-functions via a fluorescent reaction to calcium-flow (which, you guessed it, is related to cell-activity)(see Nature 493, p467). The calcium-indicator is actually expressed by a transgenic line of fish (or other even less cuddly animals like fruit-flies, clamped under a microscope with their legs moving freely on a little ball). As reporte